Case Report: Encephalitis, with Brainstem Involvement, Following Checkpoint Inhibitor Therapy in Metastatic Melanoma
نویسندگان
چکیده
منابع مشابه
Combined checkpoint inhibitor therapy causing diabetic ketoacidosis in metastatic melanoma
BACKGROUND There has been a significant improvement in survival of advanced malignancies with the advent of checkpoint inhibitors. These newer treatment modalities come with a wide spectrum of unique side effects, termed immune related adverse events (irAE), ranging from mild skin rash to severe colitis. Included in that spectrum is the rare side effect of autoimmune diabetes mellitus. Despite ...
متن کاملThrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy
BACKGROUND Immune checkpoint inhibitors, including antibodies against programmed death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 (CTLA-4), are being used with increasing frequency for the treatment of cancer. Immune-related adverse events (irAEs) including colitis, dermatitis, and pneumonitis are well described, but less frequent events are now emerging with larger numbers of patients treat...
متن کاملSevere acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma
Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis, endocrinopathies and nephritis. Here, we report a case of a 75-year-old man with metastatic malignant melanoma treated with a combination of nivolumab (an...
متن کاملPD-1 Checkpoint Inhibitor Associated Autoimmune Encephalitis
OBJECTIVE To report first-hand narrative experience of autoimmune encephalitis and to briefly review currently available evidence of autoimmune encephalitis in cancer patients treated with immune checkpoint inhibitors. SETTING A case study is presented on the management of a patient who developed autoimmune encephalitis during nivolumab monotherapy occurring after 28 weeks on anti-PD-1 monoth...
متن کاملMetastatic melanoma and vitiligo: a case report.
Different clinical studies report the connection between malignant melanoma (MM) and vitiligo, as the etiology of both diseases evolves around melanocytes. A case is presented of a 70-year-old female patient with metastatic MM in lymphatic node of the right groin, which developed simultaneously with the "vitiligo-like patches" over the face and extremities. Some authors suggest that the appeara...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2017
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2016-0366